Genetics and pathogenesis of inflammatory bowel disease.
Nature
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Abstract | Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host-commensal relationship. |
Year of Publication | 2011
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Journal | Nature
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Volume | 474
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Issue | 7351
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Pages | 307-17
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Date Published | 2011 Jun 15
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ISSN | 1476-4687
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URL | |
DOI | 10.1038/nature10209
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PubMed ID | 21677747
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PubMed Central ID | PMC3204665
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Grant list | P30 DK040561 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
R01 DK083756-04 / DK / NIDDK NIH HHS / United States
P30 DK040561-15 / DK / NIDDK NIH HHS / United States
R01 DK083756 / DK / NIDDK NIH HHS / United States
P30 DK043351-20 / DK / NIDDK NIH HHS / United States
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