Genetics and pathogenesis of inflammatory bowel disease.

Nature
Authors
Keywords
Abstract

Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host-commensal relationship.

Year of Publication
2011
Journal
Nature
Volume
474
Issue
7351
Pages
307-17
Date Published
2011 Jun 15
ISSN
1476-4687
URL
DOI
10.1038/nature10209
PubMed ID
21677747
PubMed Central ID
PMC3204665
Links
Grant list
P30 DK040561 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
R01 DK083756-04 / DK / NIDDK NIH HHS / United States
P30 DK040561-15 / DK / NIDDK NIH HHS / United States
R01 DK083756 / DK / NIDDK NIH HHS / United States
P30 DK043351-20 / DK / NIDDK NIH HHS / United States