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Nature DOI:10.1038/nature10209

Genetics and pathogenesis of inflammatory bowel disease.

Publication TypeJournal Article
Year of Publication2011
AuthorsKhor, B, Gardet, A, Xavier, RJ
JournalNature
Volume474
Issue7351
Pages307-17
Date Published2011 Jun 15
ISSN1476-4687
KeywordsAnimals, Autophagy, Epithelium, Genetic Predisposition to Disease, Humans, Immunity, Innate, Inflammatory Bowel Diseases
Abstract

Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host-commensal relationship.

URLhttp://dx.doi.org/10.1038/nature10209
DOI10.1038/nature10209
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21677747?dopt=Abstract

Alternate JournalNature
PubMed ID21677747
PubMed Central IDPMC3204665
Grant ListP30 DK040561 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
R01 DK083756-04 / DK / NIDDK NIH HHS / United States
P30 DK040561-15 / DK / NIDDK NIH HHS / United States
R01 DK083756 / DK / NIDDK NIH HHS / United States
P30 DK043351-20 / DK / NIDDK NIH HHS / United States