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Nature DOI:10.1038/nature10209

Genetics and pathogenesis of inflammatory bowel disease.

Publication TypeJournal Article
Year of Publication2011
AuthorsKhor, B, Gardet, A, Xavier, RJ
JournalNature
Volume474
Issue7351
Pages307-17
Date Published2011/06/15
ISSN0028-0836
Abstract

Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host-commensal relationship.

URLhttp://dx.doi.org/10.1038/nature10209
DOI10.1038/nature10209
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21677747?dopt=Abstract