|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Papa, E, Docktor, M, Smillie, C, Weber, S, Preheim, SP, Gevers, D, Giannoukos, G, Ciulla, D, Tabbaa, D, Ingram, J, Schauer, DB, Ward, DV, Korzenik, JR, Xavier, RJ, Bousvaros, A, Alm, EJ|
Pediatric inflammatory bowel disease (IBD) is challenging to diagnose because of the non-specificity of symptoms; an unequivocal diagnosis can only be made using colonoscopy, which clinicians are reluctant to recommend for children. Diagnosis of pediatric IBD is therefore frequently delayed, leading to inappropriate treatment plans and poor outcomes. We investigated the use of 16S rRNA sequencing of fecal samples and new analytical methods to assess differences in the microbiota of children with IBD and other gastrointestinal disorders.