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PloS one DOI:10.1371/journal.pone.0039242

Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.

Publication TypeJournal Article
Year of Publication2012
AuthorsPapa, E, Docktor, M, Smillie, C, Weber, S, Preheim, SP, Gevers, D, Giannoukos, G, Ciulla, D, Tabbaa, D, Ingram, J, Schauer, DB, Ward, DV, Korzenik, JR, Xavier, RJ, Bousvaros, A, Alm, EJ
JournalPloS one
Date Published2012/01/01

Pediatric inflammatory bowel disease (IBD) is challenging to diagnose because of the non-specificity of symptoms; an unequivocal diagnosis can only be made using colonoscopy, which clinicians are reluctant to recommend for children. Diagnosis of pediatric IBD is therefore frequently delayed, leading to inappropriate treatment plans and poor outcomes. We investigated the use of 16S rRNA sequencing of fecal samples and new analytical methods to assess differences in the microbiota of children with IBD and other gastrointestinal disorders.