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Science (New York, N.Y.) DOI:10.1126/science.1171347

Transcriptional regulatory circuits: predicting numbers from alphabets.

Publication TypeJournal Article
Year of Publication2009
AuthorsKim, HD, Shay, T, O'Shea, EK, Regev, A
JournalScience (New York, N.Y.)
Volume325
Issue5939
Pages429-32
Date Published2009/07/24
ISSN0036-8075
Abstract

Transcriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=19628860
DOI10.1126/science.1171347
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/19628860?dopt=Abstract