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Future medicinal chemistry DOI:10.4155/fmc.12.178

Hits, leads and drugs against malaria through diversity-oriented synthesis.

Publication TypeJournal Article
Year of Publication2012
AuthorsDandapani, S, Comer, E, Duvall, JR, Munoz, B
JournalFuture medicinal chemistry
Volume4
Issue18
Pages2279-94
Date Published2012/12/01
ISSN1756-8919
Abstract

Malaria is a devastating infectious disease and approximately half the world's population is at risk. Since vaccination is not yet available, small-molecule-based medicines are currently the best option for the treatment of patients suffering from malaria and combating the spread of infection. Development of resistance against existing drugs has created a need for new types of small molecules to be screened against Plasmodium falciparum, the etiological agent of malaria. The advent of diversity-oriented synthesis has enabled access to novel chemical structures. Evaluation of diversity-oriented synthesis compounds in phenotypic assays for growth inhibition of P. falciparum has resulted in novel hits, leads and even investigational drugs against malaria.

URLhttp://www.future-science.com/doi/abs/10.4155/fmc.12.178?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI10.4155/fmc.12.178
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23234551?dopt=Abstract