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Nature reviews. Genetics DOI:10.1038/nrg3382

The nature of confounding in genome-wide association studies.

Publication TypeJournal Article
Year of Publication2012
AuthorsVilhjálmsson, BJ, Nordborg, M
JournalNature reviews. Genetics
Volume14
Issue1
Pages1-2
Date Published2012/12/18
ISSN1471-0056
Abstract

The authors argue that population structure per se is not a problem in genome-wide association studies - the true sources are the environment and the genetic background, and the latter is greatly underappreciated. They conclude that mixed models effectively address this issue.

URLhttp://dx.doi.org/10.1038/nrg3382
DOI10.1038/nrg3382
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23165185?dopt=Abstract