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Nat Rev Genet DOI:10.1038/nrg3382

The nature of confounding in genome-wide association studies.

Publication TypeJournal Article
Year of Publication2013
AuthorsVilhjálmsson, BJ, Nordborg, M
JournalNat Rev Genet
Volume14
Issue1
Pages1-2
Date Published2013 Jan
ISSN1471-0064
KeywordsAnimals, Confounding Factors (Epidemiology), Gene-Environment Interaction, Genome-Wide Association Study, Humans
Abstract

The authors argue that population structure per se is not a problem in genome-wide association studies - the true sources are the environment and the genetic background, and the latter is greatly underappreciated. They conclude that mixed models effectively address this issue.

URLhttp://dx.doi.org/10.1038/nrg3382
DOI10.1038/nrg3382
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23165185?dopt=Abstract

Alternate JournalNat. Rev. Genet.
PubMed ID23165185
Grant ListHG002790 / HG / NHGRI NIH HHS / United States