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Circ Cardiovasc Genet DOI:10.1161/CIRCGENETICS.112.962787

Impact of ancestry and common genetic variants on QT interval in African Americans.

Publication TypeJournal Article
Year of Publication2012
AuthorsJ Smith, G, Avery, CL, Evans, DS, Nalls, MA, Meng, YA, Smith, EN, Palmer, C, Tanaka, T, Mehra, R, Butler, AM, Young, T, Buxbaum, SG, Kerr, KF, Berenson, GS, Schnabel, RB, Li, G, Ellinor, PT, Magnani, JW, Chen, W, Bis, JC, J Curb, D, Hsueh, W-C, Rotter, JI, Liu, Y, Newman, AB, Limacher, MC, North, KE, Reiner, AP, P Quibrera, M, Schork, NJ, Singleton, AB, Psaty, BM, Soliman, EZ, Solomon, AJ, Srinivasan, SR, Alonso, A, Wallace, R, Redline, S, Zhang, Z-M, Post, WS, Zonderman, AB, Taylor, HA, Murray, SS, Ferrucci, L, Arking, DE, Evans, MK, Fox, ER, Sotoodehnia, N, Heckbert, SR, Whitsel, EA, Newton-Cheh, C
Corporate AuthorsCARe and COGENT consortia
JournalCirc Cardiovasc Genet
Volume5
Issue6
Pages647-55
Date Published2012 Dec
ISSN1942-3268
KeywordsAdult, African Americans, Aged, Electrocardiography, European Continental Ancestry Group, Female, Genealogy and Heraldry, Genetic Variation, Genome, Human, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide
Abstract

BACKGROUND: Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval.

METHODS AND RESULTS: First, individual estimates of African and European ancestry were inferred from genome-wide single-nucleotide polymorphism (SNP) data in 7 population-based cohorts of African Americans (n=12,097) and regressed on measured QT interval from ECGs. Second, imputation was performed for 2.8 million SNPs, and a genome-wide association study of QT interval was performed in 10 cohorts (n=13,105). There was no evidence of association between genetic ancestry and QT interval (P=0.94). Genome-wide significant associations (P

CONCLUSIONS: We observed no difference in duration of cardiac repolarization with global genetic indices of African American ancestry. In addition, our genome-wide association study extends the association of polymorphisms at several loci associated with repolarization in individuals of European ancestry to include individuals of African ancestry.

URLhttp://circgenetics.ahajournals.org/cgi/pmidlookup?view=long&pmid=23166209
DOI10.1161/CIRCGENETICS.112.962787
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/23166209?dopt=Abstract

Alternate JournalCirc Cardiovasc Genet
PubMed ID23166209
PubMed Central IDPMC3568265
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