|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Noseworthy, PA, Peloso, GM, Hwang, S-J, Larson, MG, Levy, D, O'Donnell, CJ, Newton-Cheh, C|
|Journal||Ann Noninvasive Electrocardiol|
|Date Published||2012 Oct|
|Keywords||Adult, Cohort Studies, Coronary Disease, Death, Sudden, Cardiac, Electrocardiography, Female, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Proportional Hazards Models, Risk, Risk Factors, United States|
BACKGROUND: The association between QT interval and mortality has been demonstrated in large, prospective population-based studies, but the strength of the association varies considerably based on the method of heart rate correction. We examined the QT-mortality relationship in the Framingham Heart Study (FHS).
METHODS: Participants in the first (original cohort, n = 2,365) and second generation (offspring cohort, n = 4,530) cohorts were included in this study with a mean follow up of 27.5 years. QT interval measurements were obtained manually using a reproducible digital caliper technique.
RESULTS: Using Cox proportional hazards regression adjusting for age and sex, a 20 millisecond increase in QTc (using Bazett's correction; QT/RR(1/2) interval) was associated with a modest increase in risk of all-cause mortality (HR 1.14, 95% CI 1.10-1.18, P
CONCLUSION: In FHS, there is evidence of a graded relation between QTc and all-cause mortality, CHD death, and SCD; however, this association is attenuated by adjustment for RR interval. These data confirm that using Bazett's heart rate correction, QTc, overestimates the association with mortality. An association with all-cause mortality persists despite a more complete adjustment for heart rate and known cardiovascular risk factors.
|Alternate Journal||Ann Noninvasive Electrocardiol|
|PubMed Central ID||PMC3481183|
|Grant List||N01-HC-25195 / HC / NHLBI NIH HHS / United States |
R01 HL098283 / HL / NHLBI NIH HHS / United States
HL098283 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
K23 HL080025 / HL / NHLBI NIH HHS / United States
HL080025 / HL / NHLBI NIH HHS / United States