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PLoS One DOI:10.1371/journal.pone.0044424

Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.

Publication TypeJournal Article
Year of Publication2012
AuthorsFlorez, JC, Jablonski, KA, McAteer, JB, Franks, PW, Mason, CC, Mather, K, Horton, E, Goldberg, R, Dabelea, D, Kahn, SE, Arakaki, RF, Shuldiner, AR, Knowler, WC
Corporate AuthorsDiabetes Prevention Program Research Group
JournalPLoS One
Volume7
Issue9
Pagese44424
Date Published2012
ISSN1932-6203
KeywordsAlleles, Blood Glucose, Cohort Studies, Diabetes Mellitus, Type 2, Ethnic Groups, Fasting, Genetic Predisposition to Disease, Genotype, Humans, Insulin, Life Style, Metformin, Placebos, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Proportional Hazards Models, Regression Analysis, Risk
Abstract

Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk for diabetes were randomized to placebo, lifestyle modification or metformin for diabetes prevention. We genotyped previously reported polymorphisms (or their proxies) in/near G6PC2, MTNR1B, GCK, DGKB, GCKR, ADCY5, MADD, CRY2, ADRA2A, FADS1, PROX1, SLC2A2, GLIS3, C2CD4B, IGF1, and IRS1 in 3,548 Diabetes Prevention Program participants. We analyzed variants for association with baseline glycemic traits, incident diabetes and their interaction with response to metformin or lifestyle intervention. We replicated associations with fasting glucose at MTNR1B (P

URLhttp://dx.plos.org/10.1371/journal.pone.0044424
DOI10.1371/journal.pone.0044424
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22984506?dopt=Abstract

Alternate JournalPLoS ONE
PubMed ID22984506
PubMed Central IDPMC3439414
Grant ListU01DK048489 / DK / NIDDK NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
R01 DK072041 / DK / NIDDK NIH HHS / United States
UL1 TR000041 / TR / NCATS NIH HHS / United States
P30 DK017047 / DK / NIDDK NIH HHS / United States