Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Florez, JC, Jablonski, KA, McAteer, JB, Franks, PW, Mason, CC, Mather, K, Horton, E, Goldberg, R, Dabelea, D, Kahn, SE, Arakaki, RF, Shuldiner, AR, Knowler, WC |
Corporate Authors | Diabetes Prevention Program Research Group |
Journal | PLoS One |
Volume | 7 |
Issue | 9 |
Pages | e44424 |
Date Published | 2012 |
ISSN | 1932-6203 |
Keywords | Alleles, Blood Glucose, Cohort Studies, Diabetes Mellitus, Type 2, Ethnic Groups, Fasting, Genetic Predisposition to Disease, Genotype, Humans, Insulin, Life Style, Metformin, Placebos, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Proportional Hazards Models, Regression Analysis, Risk |
Abstract | Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk for diabetes were randomized to placebo, lifestyle modification or metformin for diabetes prevention. We genotyped previously reported polymorphisms (or their proxies) in/near G6PC2, MTNR1B, GCK, DGKB, GCKR, ADCY5, MADD, CRY2, ADRA2A, FADS1, PROX1, SLC2A2, GLIS3, C2CD4B, IGF1, and IRS1 in 3,548 Diabetes Prevention Program participants. We analyzed variants for association with baseline glycemic traits, incident diabetes and their interaction with response to metformin or lifestyle intervention. We replicated associations with fasting glucose at MTNR1B (P |
URL | http://dx.plos.org/10.1371/journal.pone.0044424 |
DOI | 10.1371/journal.pone.0044424 |
Pubmed | |
Alternate Journal | PLoS ONE |
PubMed ID | 22984506 |
PubMed Central ID | PMC3439414 |
Grant List | U01DK048489 / DK / NIDDK NIH HHS / United States P30 DK079637 / DK / NIDDK NIH HHS / United States R01 DK072041 / DK / NIDDK NIH HHS / United States UL1 TR000041 / TR / NCATS NIH HHS / United States P30 DK017047 / DK / NIDDK NIH HHS / United States |
PLoS One DOI:10.1371/journal.pone.0044424
Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.
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