Scientific Publications

Transcription Factor-mediated Epigenetic Reprogramming.

Publication TypeJournal Article
AuthorsSindhu, C., Samavarchi-Tehrani P., and Meissner A.
AbstractInput from various signaling pathways in conjunction with specific transcription factors (TFs), noncoding RNAs, and epigenetic modifiers governs the maintenance of cellular identity. Endogenous or exogenous TFs operate within certain boundaries, which are set, in part, by the cell type-specific epigenetic landscape. Ectopic expression of selected TFs can override the cellular identity and induce reprogramming to alternative fates. In this minireview, we summarize many of the classic examples and a large number of recent studies that have taken advantage of TF-mediated reprogramming to produce cell types of biomedical relevance.
Year of Publication2012
JournalThe Journal of biological chemistry
Date Published (YYYY/MM/DD)2012/09/07
ISSN Number0021-9258