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J Biol Chem DOI:10.1074/jbc.R111.319046

Transcription factor-mediated epigenetic reprogramming.

Publication TypeJournal Article
Year of Publication2012
AuthorsSindhu, C, Samavarchi-Tehrani, P, Meissner, A
JournalJ Biol Chem
Date Published2012 Sep 07
KeywordsCell Dedifferentiation, Epigenesis, Genetic, Humans, Transcription Factors

Input from various signaling pathways in conjunction with specific transcription factors (TFs), noncoding RNAs, and epigenetic modifiers governs the maintenance of cellular identity. Endogenous or exogenous TFs operate within certain boundaries, which are set, in part, by the cell type-specific epigenetic landscape. Ectopic expression of selected TFs can override the cellular identity and induce reprogramming to alternative fates. In this minireview, we summarize many of the classic examples and a large number of recent studies that have taken advantage of TF-mediated reprogramming to produce cell types of biomedical relevance.


Alternate JournalJ. Biol. Chem.
PubMed ID22952239
PubMed Central IDPMC3438925
Grant ListP01 GM099117 / GM / NIGMS NIH HHS / United States
U01 ES017155 / ES / NIEHS NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States
U01ES017155 / ES / NIEHS NIH HHS / United States