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Annu Rev Phytopathol DOI:10.1146/annurev-phyto-081211-172912

Mechanisms and evolution of virulence in oomycetes.

Publication TypeJournal Article
Year of Publication2012
AuthorsH Y Jiang, R, Tyler, BM
JournalAnnu Rev Phytopathol
Date Published2012
KeywordsAnimals, Evolution, Molecular, Gene Transfer, Horizontal, Genome, Host Specificity, Host-Pathogen Interactions, Oomycetes, Plant Diseases, Plant Immunity, Plants, Virulence, Virulence Factors

Many destructive diseases of plants and animals are caused by oomycetes, a group of eukaryotic pathogens important to agricultural, ornamental, and natural ecosystems. Understanding the mechanisms underlying oomycete virulence and the genomic processes by which those mechanisms rapidly evolve is essential to developing effective long-term control measures for oomycete diseases. Several common mechanisms underlying oomycete virulence, including protein toxins and cell-entering effectors, have emerged from comparing oomycetes with different genome characteristics, parasitic lifestyles, and host ranges. Oomycete genomes display a strongly bipartite organization in which conserved housekeeping genes are concentrated in syntenic gene-rich blocks, whereas virulence genes are dispersed into highly dynamic, repeat-rich regions. There is also evidence that key virulence genes have been acquired by horizontal transfer from other eukaryotic and prokaryotic species.


Alternate JournalAnnu Rev Phytopathol
PubMed ID22920560
Grant ListHHSN27220090018C / / PHS HHS / United States