Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Gifford, CA, Meissner, A |
Journal | Curr Opin Genet Dev |
Volume | 22 |
Issue | 5 |
Pages | 409-15 |
Date Published | 2012 Oct |
ISSN | 1879-0380 |
Keywords | Animals, Cell Differentiation, Cellular Reprogramming, DNA-Binding Proteins, Epigenesis, Genetic, Gene Expression Regulation, Humans, Kruppel-Like Transcription Factors, Octamer Transcription Factor-3, SOXB1 Transcription Factors, Transcription Factors |
Abstract | Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact with and remodel a somatic genome remains underexplored. Several recent studies have begun to provide mechanistic insights that will eventually lead to a more rational design and improved understanding of nuclear reprogramming. |
URL | http://linkinghub.elsevier.com/retrieve/pii/S0959-437X(12)00090-1 |
DOI | 10.1016/j.gde.2012.08.002 |
Pubmed | |
Alternate Journal | Curr. Opin. Genet. Dev. |
PubMed ID | 22922161 |
PubMed Central ID | PMC3490009 |
Grant List | P01 GM099117 / GM / NIGMS NIH HHS / United States U01 ES017155 / ES / NIEHS NIH HHS / United States P01GM099117 / GM / NIGMS NIH HHS / United States U01ES017155 / ES / NIEHS NIH HHS / United States |
Curr Opin Genet Dev DOI:10.1016/j.gde.2012.08.002
Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.
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