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Curr Opin Genet Dev DOI:10.1016/j.gde.2012.08.002

Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.

Publication TypeJournal Article
Year of Publication2012
AuthorsGifford, CA, Meissner, A
JournalCurr Opin Genet Dev
Date Published2012 Oct
KeywordsAnimals, Cell Differentiation, Cellular Reprogramming, DNA-Binding Proteins, Epigenesis, Genetic, Gene Expression Regulation, Humans, Kruppel-Like Transcription Factors, Octamer Transcription Factor-3, SOXB1 Transcription Factors, Transcription Factors

Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact with and remodel a somatic genome remains underexplored. Several recent studies have begun to provide mechanistic insights that will eventually lead to a more rational design and improved understanding of nuclear reprogramming.


Alternate JournalCurr. Opin. Genet. Dev.
PubMed ID22922161
PubMed Central IDPMC3490009
Grant ListP01 GM099117 / GM / NIGMS NIH HHS / United States
U01 ES017155 / ES / NIEHS NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States
U01ES017155 / ES / NIEHS NIH HHS / United States