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Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.
| Publication Type | Journal Article |
| Authors | Gifford, CA, and Meissner A. |
| Abstract | Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact with and remodel a somatic genome remains underexplored. Several recent studies have begun to provide mechanistic insights that will eventually lead to a more rational design and improved understanding of nuclear reprogramming. |
| Year of Publication | 2012 |
| Journal | Current opinion in genetics & development |
| Date Published (YYYY/MM/DD) | 2012/08/23 |
| ISSN Number | 0959-437X |
| DOI | 10.1016/j.gde.2012.08.002 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/22922161?dopt=Abstract |
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