Scientific Publications

The first synthesis of an epidiselenodiketopiperazine.

Publication TypeJournal Article
AuthorsMcMahon, TC, Stanley S., Kazyanskaya E., Hung D., and Wood JL
AbstractEpidithiodiketopiperazines (ETPs) are natural products (e.g., gliotoxin) with varied and important biological activity, which often is attributed to the redox properties of the disulfide moiety. As such, analogs with altered redox properties and similar structural characteristics would be of value to biological investigations. The use of an ETP as the point of departure in the first synthesis of an epidiselenodiketopiperazine (ESeP) and its activity against Mycobacterium tuberculosis (MTB) is reported.
Year of Publication2012
JournalOrganic letters
Volume14
Issue17
Pages4534-6
Date Published (YYYY/MM/DD)2012/09/07
ISSN Number1523-7060
DOI10.1021/ol3020094
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22913407?dopt=Abstract