|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Chan, MM, Smith, ZD, Egli, D, Regev, A, Meissner, A|
Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.