You are here

Nature genetics DOI:10.1038/ng.2382

Mouse ooplasm confers context-specific reprogramming capacity.

Publication TypeJournal Article
Year of Publication2012
AuthorsChan, MM, Smith, ZD, Egli, D, Regev, A, Meissner, A
JournalNature genetics
Volume44
Issue9
Pages978-80
Date Published2012/09/01
ISSN1061-4036
Abstract

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

URLhttp://dx.doi.org/10.1038/ng.2382
DOI10.1038/ng.2382
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22902786?dopt=Abstract