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Mol Psychiatry DOI:10.1038/mp.2012.69

Genome-wide association study of Tourette's syndrome.

Publication TypeJournal Article
Year of Publication2013
AuthorsScharf, JM, Yu, D, Mathews, CA, Neale, BM, Stewart, SE, Fagerness, JA, Evans, P, Gamazon, E, Edlund, CK, Service, SK, Tikhomirov, A, Osiecki, L, Illmann, C, Pluzhnikov, A, Konkashbaev, A, Davis, LK, Han, B, Crane, J, Moorjani, P, Crenshaw, AT, Parkin, MA, Reus, VI, Lowe, TL, Rangel-Lugo, M, Chouinard, S, Dion, Y, Girard, S, Cath, DC, Smit, JH, King, RA, Fernandez, TV, Leckman, JF, Kidd, KK, Kidd, JR, Pakstis, AJ, State, MW, Herrera, LD, Romero, R, Fournier, E, Sandor, P, Barr, CL, Phan, N, Gross-Tsur, V, Benarroch, F, Pollak, Y, Budman, CL, Bruun, RD, Erenberg, G, Naarden, AL, Lee, PC, Weiss, N, Kremeyer, B, Berrío, GB, Campbell, DD, Silgado, JCCardona, Ochoa, WC, Restrepo, SCMesa, Muller, H, Duarte, AVValencia, Lyon, GJ, Leppert, M, Morgan, J, Weiss, R, Grados, MA, Anderson, K, Davarya, S, Singer, H, Walkup, J, Jankovic, J, Tischfield, JA, Heiman, GA, Gilbert, DL, Hoekstra, PJ, Robertson, MM, Kurlan, R, Liu, C, Gibbs, JR, Singleton, A, Hardy, J, Strengman, E, Ophoff, RA, Wagner, M, Moessner, R, Mirel, DB, Posthuma, D, Sabatti, C, Eskin, E, Conti, DV, Knowles, JA, Ruiz-Linares, A, Rouleau, GA, Purcell, S, Heutink, P, Oostra, BA, McMahon, WM, Freimer, NB, Cox, NJ, Pauls, DL
Corporate AuthorsNorth American Brain Expression Consortium, UK Human Brain Expression Database
JournalMol Psychiatry
Volume18
Issue6
Pages721-8
Date Published2013 Jun
ISSN1476-5578
KeywordsAdolescent, Adult, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Chromosomes, Human, Pair 9, European Continental Ancestry Group, Female, Fibrillar Collagens, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, International Cooperation, Male, Meta-Analysis as Topic, Obsessive-Compulsive Disorder, Polymorphism, Single Nucleotide, Tourette Syndrome, Young Adult
Abstract

Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (P

URLhttp://dx.doi.org/10.1038/mp.2012.69
DOI10.1038/mp.2012.69
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22889924?dopt=Abstract

Alternate JournalMol. Psychiatry
PubMed ID22889924
PubMed Central IDPMC3605224
Grant ListU01HG004438 / HG / NHGRI NIH HHS / United States
U01 HG004438 / HG / NHGRI NIH HHS / United States
G0802462 / / Medical Research Council / United Kingdom
U01 HG004446 / HG / NHGRI NIH HHS / United States
Z01 AG000932-02 / AG / NIA NIH HHS / United States
K23 MH085057 / MH / NIMH NIH HHS / United States
K05MH076273 / MH / NIMH NIH HHS / United States
NS037484 / NS / NINDS NIH HHS / United States
MR/K01417X/1 / / Medical Research Council / United Kingdom
R01 MH061940 / MH / NIMH NIH HHS / United States
G0701075 / / Medical Research Council / United Kingdom
NS40024-07S1 / NS / NINDS NIH HHS / United States
R25 MH077823 / MH / NIMH NIH HHS / United States
P01 CA089392 / CA / NCI NIH HHS / United States
/ / Medical Research Council / United Kingdom
T32MH018268 / MH / NIMH NIH HHS / United States
R01MH061940 / MH / NIMH NIH HHS / United States
U01 NS040024 / NS / NINDS NIH HHS / United States
NS40024 / NS / NINDS NIH HHS / United States
K25 HL080079 / HL / NHLBI NIH HHS / United States
P30 NS062691 / NS / NINDS NIH HHS / United States
R01 NS016648 / NS / NINDS NIH HHS / United States
K08 MH099424 / MH / NIMH NIH HHS / United States
P01MH049351 / MH / NIMH NIH HHS / United States
T32 MH018268 / MH / NIMH NIH HHS / United States
MH085057 / MH / NIMH NIH HHS / United States
K05 MH076273 / MH / NIMH NIH HHS / United States
HHSN268200782096C / HG / NHGRI NIH HHS / United States
U01 HG004422 / HG / NHGRI NIH HHS / United States
P01 MH049351 / MH / NIMH NIH HHS / United States
R01 DA013423 / DA / NIDA NIH HHS / United States
R01 NS040024 / NS / NINDS NIH HHS / United States
NS043538 / NS / NINDS NIH HHS / United States
Z01 AG000932 / AG / NIA NIH HHS / United States
U24 MH068457 / MH / NIMH NIH HHS / United States
NS16648-29S1 / NS / NINDS NIH HHS / United States
R01 MH092293 / MH / NIMH NIH HHS / United States
U10 AA008401 / AA / NIAAA NIH HHS / United States
HHSN268200782096C / / PHS HHS / United States
R01 NS037484 / NS / NINDS NIH HHS / United States
MH079489 / MH / NIMH NIH HHS / United States
G0901254 / / Medical Research Council / United Kingdom
U54 RR020278 / RR / NCRR NIH HHS / United States
R01 NS043538 / NS / NINDS NIH HHS / United States
NS16648 / NS / NINDS NIH HHS / United States