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Cell research DOI:10.1038/cr.2012.115

Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.

Publication TypeJournal Article
Year of Publication2012
AuthorsKonieczkowski, DJ, Garraway, LA
JournalCell research
Date Published2012/07/31
ISSN1001-0602
Abstract

Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the initiation of therapy.

URLhttp://dx.doi.org/10.1038/cr.2012.115
DOI10.1038/cr.2012.115
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22847744?dopt=Abstract