Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.
Cell Res
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Abstract | Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the initiation of therapy. |
Year of Publication | 2013
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Journal | Cell Res
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Volume | 23
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Issue | 1
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Pages | 13-4
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Date Published | 2013 Jan
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ISSN | 1748-7838
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URL | |
DOI | 10.1038/cr.2012.115
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PubMed ID | 22847744
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PubMed Central ID | PMC3541651
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Grant list | T32 GM007753 / GM / NIGMS NIH HHS / United States
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