Scientific Publications

Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.

Publication TypeJournal Article
AuthorsKonieczkowski, DJ, and Garraway LA
AbstractTwo recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the initiation of therapy.
Year of Publication2012
JournalCell research
Date Published (YYYY/MM/DD)2012/07/31
ISSN Number1001-0602
DOI10.1038/cr.2012.115
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22847744?dopt=Abstract