|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Konieczkowski, DJ, Garraway, LA|
Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the initiation of therapy.