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International journal of endocrinology DOI:10.1155/2012/925143

Chemical Methods to Induce Beta-Cell Proliferation.

Publication TypeJournal Article
Year of Publication2012
AuthorsVetere, A, Wagner, BK
JournalInternational journal of endocrinology
Volume2012
Pages925143
Date Published2012/01/01
ISSN1687-8337
Abstract

Pancreatic beta-cell regeneration, for example, by inducing proliferation, remains an important goal in developing effective treatments for diabetes. However, beta cells have mainly been considered quiescent. This "static" view has recently been challenged by observations of relevant physiological conditions in which metabolic stress is compensated by an increase in beta-cell mass. Understanding the molecular mechanisms underlining these process could open the possibility of developing novel small molecules to increase beta-cell mass. Several cellular cell-cycle and signaling proteins provide attractive targets for high throughput screening, and recent advances in cell culture have enabled phenotypic screening for small molecule-induced beta-cell proliferation. We present here an overview of the current trends involving small-molecule approaches to induce beta-cell regeneration by proliferation.

DOI10.1155/2012/925143
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22811709?dopt=Abstract