Recent Broad Publications

Remodelling of a homeobox gene cluster by multiple independent gene reunions in Drosophila.
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Anemia: progress in molecular mechanisms and therapies.
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Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.
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Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.
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Large-scale inter-laboratory study to develop, analytically validate and apply highly multiplexed, quantitative peptide assays to measure cancer-relevant proteins in plasma.
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Scientific Publications

Publication Type	Journal Article
Authors	Sanjana, NE, Levanon EY, Hueske EA, Ambrose JM, and Li JB
Abstract	Changes in neural activity influence synaptic plasticity/scaling, gene expression, and epigenetic modifications. We present the first evidence that short-term and persistent changes in neural activity can alter adenosine-to-inosine (A-to-I) RNA editing, a post transcriptional site-specific modification found in several neuron-specific transcripts. In rat cortical neuron cultures, activity-dependent changes in A-to-I RNA editing in coding exons are present after 6 hours of high potassium depolarization but not after 1 hour and require calcium entry into neurons. When treatments are extended from hours to days, we observe a negative feedback phenomenon: Chronic depolarization increases editing at many sites and chronic silencing decreases editing. We present several different modulations of neural activity that change the expression of different mRNA isoforms through editing.
Year of Publication	2012
Journal	Genetics
Date Published (YYYY/MM/DD)	2012/06/19
ISSN Number	0016-6731
DOI	10.1534/genetics.112.141200
PubMed	http://www.ncbi.nlm.nih.gov/pubmed/22714409?dopt=Abstract