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Cell Stem Cell DOI:10.1016/j.stem.2012.05.010

The promise and perils of stem cell therapeutics.

Publication TypeJournal Article
Year of Publication2012
AuthorsDaley, GQ
JournalCell Stem Cell
Volume10
Issue6
Pages740-9
Date Published2012 Jun 14
ISSN1875-9777
KeywordsCell- and Tissue-Based Therapy, Clinical Trials as Topic, Humans, Regeneration, Stem Cells, Wound Healing
Abstract

Stem cells are the seeds of tissue repair and regeneration and a promising source for novel therapies. However, apart from hematopoietic stem cell (HSC) transplantation, essentially all other stem cell treatments remain experimental. High hopes have inspired numerous clinical trials, but it has been difficult to obtain unequivocal evidence for robust clinical benefit. In recent years, unproven therapies have been widely practiced outside the standard clinical trial network, threatening the cause of legitimate clinical investigation. Numerous challenges and technical barriers must be overcome before novel stem cell therapies can achieve meaningful clinical impact.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1934-5909(12)00243-3
DOI10.1016/j.stem.2012.05.010
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22704514?dopt=Abstract

Alternate JournalCell Stem Cell
PubMed ID22704514
PubMed Central IDPMC3629702
Grant ListR24DK092760 / DK / NIDDK NIH HHS / United States
P50 HG005550 / HG / NHGRI NIH HHS / United States
RC2-HL102815 / HL / NHLBI NIH HHS / United States
U01 HL100001 / HL / NHLBI NIH HHS / United States
RC2 HL102815 / HL / NHLBI NIH HHS / United States
UO1-HL100001 / HL / NHLBI NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R24 DK092760 / DK / NIDDK NIH HHS / United States
RC4-DK090913 / DK / NIDDK NIH HHS / United States
RC4 DK090913 / DK / NIDDK NIH HHS / United States
P50HG005550 / HG / NHGRI NIH HHS / United States