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Science DOI:10.1126/science.1214977

Evolutionary diversity of the mitochondrial calcium uniporter.

Publication TypeJournal Article
Year of Publication2012
AuthorsBick, AG, Calvo, SE, Mootha, VK
Date Published2012 May 18
KeywordsAnimals, Bacteria, Bacterial Proteins, Calcium Channels, Calcium-Binding Proteins, Cation Transport Proteins, Eukaryota, Evolution, Molecular, Genome, Humans, Mitochondria, Mitochondrial Membrane Transport Proteins, Phylogeny, Protein Structure, Tertiary, Proteome

Calcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life, but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria.


Alternate JournalScience
PubMed ID22605770
PubMed Central IDPMC3518847
Grant ListR01 GM097136 / GM / NIGMS NIH HHS / United States
T32GM007753-33 / GM / NIGMS NIH HHS / United States
R01GM077465 / GM / NIGMS NIH HHS / United States
T32 GM007753 / GM / NIGMS NIH HHS / United States
R01GM097136 / GM / NIGMS NIH HHS / United States
R01 GM077465 / GM / NIGMS NIH HHS / United States