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Science (New York, N.Y.) DOI:10.1126/science.1214977

Evolutionary diversity of the mitochondrial calcium uniporter.

Publication TypeJournal Article
Year of Publication2012
AuthorsBick, AG, Calvo, SE, Mootha, VK
JournalScience (New York, N.Y.)
Volume336
Issue6083
Pages886
Date Published2012/05/18
ISSN0036-8075
Abstract

Calcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life, but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=short&pmid=22605770
DOI10.1126/science.1214977
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22605770?dopt=Abstract