Scientific Publications

Evolutionary diversity of the mitochondrial calcium uniporter.

Publication TypeJournal Article
AuthorsBick, AG, Calvo SE, and Mootha VK
AbstractCalcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life, but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria.
Year of Publication2012
JournalScience (New York, N.Y.)
Volume336
Issue6083
Pages886
Date Published (YYYY/MM/DD)2012/05/18
ISSN Number0036-8075
DOI10.1126/science.1214977
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22605770?dopt=Abstract