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PloS one DOI:10.1371/journal.pone.0036947

Inferring carbon sources from gene expression profiles using metabolic flux models.

Publication TypeJournal Article
Year of Publication2012
AuthorsBrandes, A, Lun, DS, Ip, K, Zucker, J, Colijn, C, Weiner, B, Galagan, JE
JournalPloS one
Volume7
Issue5
Pagese36947
Date Published2012/01/01
Abstract

Bacteria have evolved the ability to efficiently and resourcefully adapt to changing environments. A key means by which they optimize their use of available nutrients is through adjustments in gene expression with consequent changes in enzyme activity. We report a new method for drawing environmental inferences from gene expression data. Our method prioritizes a list of candidate carbon sources for their compatibility with a gene expression profile using the framework of flux balance analysis to model the organism's metabolic network.

URLhttp://dx.plos.org/10.1371/journal.pone.0036947
DOI10.1371/journal.pone.0036947
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22606312?dopt=Abstract