Scientific Publications

Inferring carbon sources from gene expression profiles using metabolic flux models.

Publication TypeJournal Article
AuthorsBrandes, A., Lun DS, Ip K., Zucker J., Colijn C., Weiner B., and Galagan JE
AbstractBacteria have evolved the ability to efficiently and resourcefully adapt to changing environments. A key means by which they optimize their use of available nutrients is through adjustments in gene expression with consequent changes in enzyme activity. We report a new method for drawing environmental inferences from gene expression data. Our method prioritizes a list of candidate carbon sources for their compatibility with a gene expression profile using the framework of flux balance analysis to model the organism's metabolic network.
Year of Publication2012
JournalPloS one
Date Published (YYYY/MM/DD)2012/01/01