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Nat Genet DOI:10.1038/ng.2274

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Publication TypeJournal Article
Year of Publication2012
AuthorsManning, AK, Hivert, M-F, Scott, RA, Grimsby, JL, Bouatia-Naji, N, Chen, H, Rybin, D, Liu, C-T, Bielak, LF, Prokopenko, I, Amin, N, Barnes, D, Cadby, G, Hottenga, J-J, Ingelsson, E, Jackson, AU, Johnson, T, Kanoni, S, Ladenvall, C, Lagou, V, Lahti, J, Lecoeur, C, Liu, Y, Martínez-Larrad, MTeresa, Montasser, ME, Navarro, P, Perry, JRB, Rasmussen-Torvik, LJ, Salo, P, Sattar, N, Shungin, D, Strawbridge, RJ, Tanaka, T, van Duijn, CM, An, P, de Andrade, M, Andrews, JS, Aspelund, T, Atalay, M, Aulchenko, ii, Y, Balkau, B, Bandinelli, S, Beckmann, JS, Beilby, JP, Bellis, C, Bergman, RN, Blangero, J, Boban, M, Boehnke, M, Boerwinkle, E, Bonnycastle, LL, Boomsma, DI, Borecki, IB, Böttcher, Y, Bouchard, C, Brunner, E, Budimir, D, Campbell, H, Carlson, O, Chines, PS, Clarke, R, Collins, FS, Corbaton-Anchuelo, A, Couper, D, de Faire, U, Dedoussis, GV, Deloukas, P, Dimitriou, M, Egan, JM, Eiriksdottir, G, Erdos, MR, Eriksson, JG, Eury, E, Ferrucci, L, Ford, I, Forouhi, NG, Fox, CS, Franzosi, MGrazia, Franks, PW, Frayling, TM, Froguel, P, Galan, P, de Geus, E, Gigante, B, Glazer, NL, Goel, A, Groop, L, Gudnason, V, Hallmans, G, Hamsten, A, Hansson, O, Harris, TB, Hayward, C, Heath, S, Hercberg, S, Hicks, AA, Hingorani, A, Hofman, A, Hui, J, Hung, J, Jarvelin, M-R, Jhun, MA, Johnson, PCD, J Jukema, W, Jula, A, Kao, WH, Kaprio, J, Kardia, SLR, Keinänen-Kiukaanniemi, S, Kivimaki, M, Kolcic, I, Kovacs, P, Kumari, M, Kuusisto, J, Kyvik, KOhm, Laakso, M, Lakka, T, Lannfelt, L, G Lathrop, M, Launer, LJ, Leander, K, Li, G, Lind, L, Lindström, J, Lobbens, S, Loos, RJF, Luan, J'an, Lyssenko, V, Mägi, R, Magnusson, PKE, Marmot, M, Meneton, P, Mohlke, KL, Mooser, V, Morken, MA, Miljkovic, I, Narisu, N, O'Connell, J, Ong, KK, Oostra, BA, Palmer, LJ, Palotie, A, Pankow, JS, Peden, JF, Pedersen, NL, Pehlic, M, Peltonen, L, Penninx, B, Pericic, M, Perola, M, Pérusse, L, Peyser, PA, Polasek, O, Pramstaller, PP, Province, MA, Räikkönen, K, Rauramaa, R, Rehnberg, E, Rice, K, Rotter, JI, Rudan, I, Ruokonen, A, Saaristo, T, Sabater-Lleal, M, Salomaa, V, Savage, DB, Saxena, R, Schwarz, P, Seedorf, U, Sennblad, B, Serrano-Rios, M, Shuldiner, AR, Sijbrands, EJG, Siscovick, DS, Smit, JH, Small, KS, Smith, NL, Smith, AVernon, Stančáková, A, Stirrups, K, Stumvoll, M, Sun, YV, Swift, AJ, Tönjes, A, Tuomilehto, J, Trompet, S, Uitterlinden, AG, Uusitupa, M, Vikström, M, Vitart, V, Vohl, M-C, Voight, BF, Vollenweider, P, Waeber, G, Waterworth, DM, Watkins, H, Wheeler, E, Widén, E, Wild, SH, Willems, SM, Willemsen, G, Wilson, JF, Witteman, JCM, Wright, AF, Yaghootkar, H, Zelenika, D, Zemunik, T, Zgaga, L, Wareham, NJ, McCarthy, MI, Barroso, I, Watanabe, RM, Florez, JC, Dupuis, J, Meigs, JB, Langenberg, C
Corporate AuthorsDIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Multiple Tissue Human Expression Resource (MUTHER) Consortium
JournalNat Genet
Volume44
Issue6
Pages659-69
Date Published2012 May 13
ISSN1546-1718
KeywordsBlood Glucose, Body Mass Index, Cholesterol, HDL, Diabetes Mellitus, Type 2, Genome-Wide Association Study, Humans, Insulin, Insulin Resistance, Polymorphism, Single Nucleotide
Abstract

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P

URLhttp://dx.doi.org/10.1038/ng.2274
DOI10.1038/ng.2274
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22581228?dopt=Abstract

Alternate JournalNat. Genet.
PubMed ID22581228
PubMed Central IDPMC3613127
Grant ListR01 DK078616 / DK / NIDDK NIH HHS / United States
CZB/4/710 / / Chief Scientist Office / United Kingdom
MC_UP_A100_1003 / / Medical Research Council / United Kingdom
G19/35 / / Medical Research Council / United Kingdom
G0100222 / / Medical Research Council / United Kingdom
MC_U127561128 / / Medical Research Council / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
S10 RR029392 / RR / NCRR NIH HHS / United States
G8802774 / / Medical Research Council / United Kingdom
G0902037 / / Medical Research Council / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
MC_U137686857 / / Medical Research Council / United Kingdom
R01 HL105756 / HL / NHLBI NIH HHS / United States
MC_U106179471 / / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
MC_U106179472 / / Medical Research Council / United Kingdom
G1002084 / / Medical Research Council / United Kingdom
MC_PC_U127592696 / / Medical Research Council / United Kingdom
G0701863 / / Medical Research Council / United Kingdom
K24 DK080140 / DK / NIDDK NIH HHS / United States
090532 / / Wellcome Trust / United Kingdom
R37 MH059490 / MH / NIMH NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
MC_U127592696 / / Medical Research Council / United Kingdom
091551 / / Wellcome Trust / United Kingdom
G0900339 / / Medical Research Council / United Kingdom
RG/07/008/23674 / / British Heart Foundation / United Kingdom