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Nature methods DOI:10.1038/nmeth.1984

An image analysis toolbox for high-throughput C. elegans assays.

Publication TypeJournal Article
Year of Publication2012
AuthorsWählby, C, Kamentsky, L, Liu, ZH, Riklin-Raviv, T, Conery, AL, O'Rourke, EJ, Sokolnicki, KL, Visvikis, O, Ljosa, V, Irazoqui, JE, Golland, P, Ruvkun, G, Ausubel, FM, Carpenter, AE
JournalNature methods
Date Published2012/04/22

We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease.