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Bioorganic & medicinal chemistry letters DOI:10.1016/j.bmcl.2012.02.035

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.

Publication TypeJournal Article
Year of Publication2012
AuthorsYoungsaye, W, Dockendorff, C, Vincent, B, Hartland, CL, Bittker, JA, Dandapani, S, Palmer, M, Whitesell, L, Lindquist, S, Schreiber, SL, Munoz, B
JournalBioorganic & medicinal chemistry letters
Volume22
Issue9
Pages3362-5
Date Published2012/05/01
ISSN0960-894X
Abstract

Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0960-894X(12)00227-2
DOI10.1016/j.bmcl.2012.02.035
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22497765?dopt=Abstract