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Nat Rev Genet DOI:10.1038/nrg3187

Harnessing genomics and genome biology to understand malaria biology.

Publication TypeJournal Article
Year of Publication2012
AuthorsVolkman, SK, Neafsey, DE, Schaffner, SF, Park, DJ, Wirth, DF
JournalNat Rev Genet
Date Published2012 Apr 12
KeywordsAnimals, Anopheles, Antimalarials, Drug Resistance, Female, Genetic Linkage, Genetic Loci, Genome, Protozoan, Genomics, Humans, Malaria, Male, Plasmodium falciparum, Selection, Genetic

Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being leveraged to identify genetic loci under selection in the malaria parasite and to find variants that are associated with key clinical phenotypes, such as drug resistance. This article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.


Alternate JournalNat. Rev. Genet.
PubMed ID22495435