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Annu Rev Immunol DOI:10.1146/annurev-immunol-020711-074948

Autophagy and the immune system.

Publication TypeJournal Article
Year of Publication2012
AuthorsKuballa, P, Nolte, WM, Castoreno, AB, Xavier, RJ
JournalAnnu Rev Immunol
Volume30
Pages611-46
Date Published2012
ISSN1545-3278
KeywordsAdaptive Immunity, Animals, Autophagy, Humans, Immune System, Immunity, Innate, Infection
Abstract

Stressors ranging from nutrient deprivation to immune signaling can induce the degradation of cytoplasmic material by a process known as autophagy. Increasingly, research on autophagy has begun to focus on its role in inflammation and the immune response. Autophagy acts as an immune effector that mediates pathogen clearance. The roles of autophagy bridge both the innate and adaptive immune systems and include functions in thymic selection, antigen presentation, promotion of lymphocyte homeostasis and survival, and regulation of cytokine production. In this review, we discuss the mechanisms by which autophagy is regulated, as well as the functions of autophagy and autophagy proteins in immunity and inflammation.

URLhttp://arjournals.annualreviews.org/doi/full/10.1146/annurev-immunol-020711-074948?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI10.1146/annurev-immunol-020711-074948
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22449030?dopt=Abstract

Alternate JournalAnnu. Rev. Immunol.
PubMed ID22449030
Grant ListRC1 DK086502 / DK / NIDDK NIH HHS / United States
5U01DK062432 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
RC1DK086502 / DK / NIDDK NIH HHS / United States
P30DK043351 / DK / NIDDK NIH HHS / United States
R01 DK064869 / DK / NIDDK NIH HHS / United States
5R01DK083756 / DK / NIDDK NIH HHS / United States
5R01DK064869 / DK / NIDDK NIH HHS / United States
R01 DK083756 / DK / NIDDK NIH HHS / United States