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Cancer cell DOI:10.1016/j.ccr.2012.03.001

A tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma.

Publication TypeJournal Article
Year of Publication2012
AuthorsRheinbay, E, Louis, DN, Bernstein, BE, Suvà, ML
JournalCancer cell
Volume21
Issue3
Pages329-31
Date Published2012/03/20
ISSN1535-6108
Abstract

Recent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration of a modifiable histone residue in human cancer.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1535-6108(12)00084-0
DOI10.1016/j.ccr.2012.03.001
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22439930?dopt=Abstract