Scientific Publications

A tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma.

Publication TypeJournal Article
AuthorsRheinbay, E., Louis DN, Bernstein BE, and Suvà ML
AbstractRecent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration of a modifiable histone residue in human cancer.
Year of Publication2012
JournalCancer cell
Volume21
Issue3
Pages329-31
Date Published (YYYY/MM/DD)2012/03/20
ISSN Number1535-6108
DOI10.1016/j.ccr.2012.03.001
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22439930?dopt=Abstract