Neuregulin signaling pathway in smoking behavior.

Transl Psychiatry
Authors
Keywords
Abstract

Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in schizophrenia, a neurodevelopmental disorder with high comorbidity to smoking. Using a Finnish twin family sample, we have previously detected association between nicotine dependence and ERBB4 (a neuregulin receptor), and linkage for smoking initiation at the ERBB4 locus on 2q33. Further, Neuregulin3 has recently been shown to associate with nicotine withdrawal in a behavioral mouse model. In this study, we scrutinized association and linkage between 15 036 common, low frequency and rare genetic variants in 10 NSP genes and phenotypes encompassing smoking and alcohol use. Using the Finnish twin family sample (N=1998 from 740 families), we detected 66 variants (representing 23 LD blocks) significantly associated (false discovery rate P

Year of Publication
2017
Journal
Transl Psychiatry
Volume
7
Issue
8
Pages
e1212
Date Published
2017 08 22
ISSN
2158-3188
DOI
10.1038/tp.2017.183
PubMed ID
28892072
PubMed Central ID
PMC5611747
Links
Grant list
Wellcome Trust / United Kingdom
R01 DA012854 / DA / NIDA NIH HHS / United States
R56 DA012854 / DA / NIDA NIH HHS / United States