Recent Broad Publications

An Adjustable Gas-Mixing Device to Increase Feasibility of In Vitro Culture of Plasmodium falciparum Parasites in the Field.
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Genetic Dissection of Anopheles gambiae Gut Epithelial Responses to Serratia marcescens.
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Comparison of illumina and 454 deep sequencing in participants failing raltegravir-based antiretroviral therapy.
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Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
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Understanding Th17 cells through systematic genomic analyses.
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Scientific Publications

Publication Type	Journal Article
Authors	Cherry, AB, and Daley GQ
Abstract	Although development leads unidirectionally toward more restricted cell fates, recent work in cellular reprogramming has proven that one cellular identity can strikingly convert into another, promising countless applications in biomedical research and paving the way for modeling diseases with patient-derived stem cells. To date, there has been little discussion of which disease models are likely to be most informative. Here, we review evidence demonstrating that, because environmental influences and epigenetic signatures are largely erased during reprogramming, patient-specific models of diseases with strong genetic bases and high penetrance are likely to prove most informative in the near term. We also discuss the implications of the new reprogramming paradigm in biomedicine and outline how reprogramming of cell identities is enhancing our understanding of cell differentiation and prospects for cellular therapies and in vivo regeneration.
Year of Publication	2012
Journal	Cell
Volume	148
Issue	6
Pages	1110-1122
Date Published (YYYY/MM/DD)	2012/03/16
ISSN Number	0092-8674
DOI	10.1016/j.cell.2012.02.031
PubMed	http://www.ncbi.nlm.nih.gov/pubmed/22424223?dopt=Abstract