Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Cherry, ABC, Daley, GQ |
Journal | Cell |
Volume | 148 |
Issue | 6 |
Pages | 1110-22 |
Date Published | 2012 Mar 16 |
ISSN | 1097-4172 |
Keywords | Cell Culture Techniques, Cellular Reprogramming, Disease, Epigenomics, Humans, Pluripotent Stem Cells, Regenerative Medicine, Stem Cell Transplantation, Stem Cells |
Abstract | Although development leads unidirectionally toward more restricted cell fates, recent work in cellular reprogramming has proven that one cellular identity can strikingly convert into another, promising countless applications in biomedical research and paving the way for modeling diseases with patient-derived stem cells. To date, there has been little discussion of which disease models are likely to be most informative. Here, we review evidence demonstrating that, because environmental influences and epigenetic signatures are largely erased during reprogramming, patient-specific models of diseases with strong genetic bases and high penetrance are likely to prove most informative in the near term. We also discuss the implications of the new reprogramming paradigm in biomedicine and outline how reprogramming of cell identities is enhancing our understanding of cell differentiation and prospects for cellular therapies and in vivo regeneration. |
URL | http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(12)00231-0 |
DOI | 10.1016/j.cell.2012.02.031 |
Pubmed | |
Alternate Journal | Cell |
PubMed ID | 22424223 |
PubMed Central ID | PMC3354575 |
Grant List | U01-HL100001 / HL / NHLBI NIH HHS / United States R01-DK70055 / DK / NIDDK NIH HHS / United States R01 DK059279 / DK / NIDDK NIH HHS / United States P50 HG005550 / HG / NHGRI NIH HHS / United States RC2-HL102815 / HL / NHLBI NIH HHS / United States R01 DK070055 / DK / NIDDK NIH HHS / United States U01 HL100001 / HL / NHLBI NIH HHS / United States RC2 HL102815 / HL / NHLBI NIH HHS / United States / / Howard Hughes Medical Institute / United States R24 DK092760 / DK / NIDDK NIH HHS / United States RC4-DK090913 / DK / NIDDK NIH HHS / United States RC4 DK090913 / DK / NIDDK NIH HHS / United States P50HG005550 / HG / NHGRI NIH HHS / United States |
Cell DOI:10.1016/j.cell.2012.02.031
Reprogramming cellular identity for regenerative medicine.
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