You are here

Cell DOI:10.1016/j.cell.2012.02.031

Reprogramming cellular identity for regenerative medicine.

Publication TypeJournal Article
Year of Publication2012
AuthorsCherry, ABC, Daley, GQ
JournalCell
Volume148
Issue6
Pages1110-22
Date Published2012 Mar 16
ISSN1097-4172
KeywordsCell Culture Techniques, Cellular Reprogramming, Disease, Epigenomics, Humans, Pluripotent Stem Cells, Regenerative Medicine, Stem Cell Transplantation, Stem Cells
Abstract

Although development leads unidirectionally toward more restricted cell fates, recent work in cellular reprogramming has proven that one cellular identity can strikingly convert into another, promising countless applications in biomedical research and paving the way for modeling diseases with patient-derived stem cells. To date, there has been little discussion of which disease models are likely to be most informative. Here, we review evidence demonstrating that, because environmental influences and epigenetic signatures are largely erased during reprogramming, patient-specific models of diseases with strong genetic bases and high penetrance are likely to prove most informative in the near term. We also discuss the implications of the new reprogramming paradigm in biomedicine and outline how reprogramming of cell identities is enhancing our understanding of cell differentiation and prospects for cellular therapies and in vivo regeneration.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0092-8674(12)00231-0
DOI10.1016/j.cell.2012.02.031
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22424223?dopt=Abstract

Alternate JournalCell
PubMed ID22424223
PubMed Central IDPMC3354575
Grant ListU01-HL100001 / HL / NHLBI NIH HHS / United States
R01-DK70055 / DK / NIDDK NIH HHS / United States
R01 DK059279 / DK / NIDDK NIH HHS / United States
P50 HG005550 / HG / NHGRI NIH HHS / United States
RC2-HL102815 / HL / NHLBI NIH HHS / United States
R01 DK070055 / DK / NIDDK NIH HHS / United States
U01 HL100001 / HL / NHLBI NIH HHS / United States
RC2 HL102815 / HL / NHLBI NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R24 DK092760 / DK / NIDDK NIH HHS / United States
RC4-DK090913 / DK / NIDDK NIH HHS / United States
RC4 DK090913 / DK / NIDDK NIH HHS / United States
P50HG005550 / HG / NHGRI NIH HHS / United States