Recent Broad Publications

Understanding Th17 cells through systematic genomic analyses.
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MOSAIK: A Hash-Based Algorithm for Accurate Next-Generation Sequencing Short-Read Mapping.
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Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history.
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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
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Scientific Publications

Publication Type	Journal Article
Authors	Cherry, AB, and Daley GQ
Abstract	Although development leads unidirectionally toward more restricted cell fates, recent work in cellular reprogramming has proven that one cellular identity can strikingly convert into another, promising countless applications in biomedical research and paving the way for modeling diseases with patient-derived stem cells. To date, there has been little discussion of which disease models are likely to be most informative. Here, we review evidence demonstrating that, because environmental influences and epigenetic signatures are largely erased during reprogramming, patient-specific models of diseases with strong genetic bases and high penetrance are likely to prove most informative in the near term. We also discuss the implications of the new reprogramming paradigm in biomedicine and outline how reprogramming of cell identities is enhancing our understanding of cell differentiation and prospects for cellular therapies and in vivo regeneration.
Year of Publication	2012
Journal	Cell
Volume	148
Issue	6
Pages	1110-1122
Date Published (YYYY/MM/DD)	2012/03/16
ISSN Number	0092-8674
DOI	10.1016/j.cell.2012.02.031
PubMed	http://www.ncbi.nlm.nih.gov/pubmed/22424223?dopt=Abstract