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Am J Hum Genet DOI:10.1016/j.ajhg.2012.01.010

Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12.

Publication TypeJournal Article
Year of Publication2012
AuthorsKurreeman, FAS, Stahl, EA, Okada, Y, Liao, K, Diogo, D, Raychaudhuri, S, Freudenberg, J, Kochi, Y, Patsopoulos, NA, Gupta, N, Sandor, C, Bang, S-Y, Lee, H-S, Padyukov, L, Suzuki, A, Siminovitch, K, Worthington, J, Gregersen, PK, Hughes, LB, Reynolds, RJ, S Bridges, L, Bae, S-C, Yamamoto, K, Plenge, RM
Corporate AuthorsCLEAR investigators
JournalAm J Hum Genet
Volume90
Issue3
Pages524-32
Date Published2012 Mar 09
ISSN1537-6605
KeywordsAlleles, Arthritis, Rheumatoid, Case-Control Studies, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 17, Computational Biology, Ethnic Groups, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Ikaros Transcription Factor, Linkage Disequilibrium, Membrane Proteins, Neoplasm Proteins, Neprilysin, Polymorphism, Single Nucleotide, Receptors, Tumor Necrosis Factor, Member 14
Abstract

We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show that we can effectively discover RA risk alleles. Thirteen putatively associated SNPs that had not yet exceeded genome-wide significance (p

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0002-9297(12)00044-4
DOI10.1016/j.ajhg.2012.01.010
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22365150?dopt=Abstract

Alternate JournalAm. J. Hum. Genet.
PubMed ID22365150
PubMed Central IDPMC3309197
Grant ListR01-AR057108 / AR / NIAMS NIH HHS / United States
P60 AR048095 / AR / NIAMS NIH HHS / United States
R01 AR057202 / AR / NIAMS NIH HHS / United States
U01 GM092691 / GM / NIGMS NIH HHS / United States
K01 DK080188 / DK / NIDDK NIH HHS / United States
R01 AR057108 / AR / NIAMS NIH HHS / United States
K01 AR060848 / AR / NIAMS NIH HHS / United States
R01-AR056768 / AR / NIAMS NIH HHS / United States
R01 AR056768 / AR / NIAMS NIH HHS / United States
U01-GM092691 / GM / NIGMS NIH HHS / United States