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Nature DOI:10.1038/nature10887

Modular regulatory principles of large non-coding RNAs.

Publication TypeJournal Article
Year of Publication2012
AuthorsGuttman, M, Rinn, JL
JournalNature
Volume482
Issue7385
Pages339-46
Date Published2012 Feb 15
ISSN1476-4687
KeywordsChromatin, Gene Expression Regulation, RNA, Untranslated, RNA-Binding Proteins
Abstract

It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.

URLhttp://dx.doi.org/10.1038/nature10887
DOI10.1038/nature10887
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22337053?dopt=Abstract

Alternate JournalNature
PubMed ID22337053
PubMed Central IDPMC4197003
Grant ListP01 GM099117 / GM / NIGMS NIH HHS / United States
R01 ES020260 / ES / NIEHS NIH HHS / United States