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Neurology DOI:10.1212/WNL.0b013e3182452b40

Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.

Publication TypeJournal Article
Year of Publication2012
AuthorsBiffi, A, Shulman, JM, Jagiella, JM, Cortellini, L, Ayres, AM, Schwab, K, Brown, DL, Silliman, SL, Selim, M, Worrall, BB, Meschia, JF, Slowik, A, De Jager, PL, Greenberg, SM, Schneider, JA, Bennett, DA, Rosand, J
Date Published2012/01/18

Accumulated evidence suggests that a variant within the CR1 gene (single nucleotide polymorphism rs6656401), known to increase risk for Alzheimer disease (AD), influences β-amyloid (Aβ) deposition in brain tissue. Given the biologic overlap between AD and cerebral amyloid angiopathy (CAA), a leading cause of intracerebral hemorrhage (ICH) in elderly individuals, we investigated whether rs6656401 increases the risk of CAA-related ICH and influences vascular Aβ deposition.