|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Biffi, A, Shulman, JM, Jagiella, JM, Cortellini, L, Ayres, AM, Schwab, K, Brown, DL, Silliman, SL, Selim, M, Worrall, BB, Meschia, JF, Slowik, A, De Jager, PL, Greenberg, SM, Schneider, JA, Bennett, DA, Rosand, J|
Accumulated evidence suggests that a variant within the CR1 gene (single nucleotide polymorphism rs6656401), known to increase risk for Alzheimer disease (AD), influences β-amyloid (Aβ) deposition in brain tissue. Given the biologic overlap between AD and cerebral amyloid angiopathy (CAA), a leading cause of intracerebral hemorrhage (ICH) in elderly individuals, we investigated whether rs6656401 increases the risk of CAA-related ICH and influences vascular Aβ deposition.