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PloS one DOI:10.1371/journal.pone.0028808

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

Publication TypeJournal Article
Year of Publication2012
AuthorsFomina-Yadlin, D, Kubicek, S, Vetere, A, He, KH, Schreiber, SL, Wagner, BK
JournalPloS one
Volume7
Issue1
Pagese28808
Date Published2012/01/01
Abstract

Expression of insulin in terminally differentiated non-beta cell types in the pancreas could be important to treating type-1 diabetes. Previous findings led us to hypothesize involvement of kinase inhibition in induction of insulin expression in pancreatic alpha cells.

URLhttp://dx.plos.org/10.1371/journal.pone.0028808
DOI10.1371/journal.pone.0028808
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22242153?dopt=Abstract