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BMC Microbiol DOI:10.1186/1471-2180-10-137

Vibrio chromosomes share common history.

Publication TypeJournal Article
Year of Publication2010
AuthorsKirkup, BC, Chang, LA, Chang, S, Gevers, D, Polz, MF
JournalBMC Microbiol
Date Published2010 May 10
KeywordsChromosomes, Cluster Analysis, Computational Biology, Evolution, Molecular, Gene Order, Genes, Bacterial, Phylogeny, Sequence Homology, Synteny, Vibrionaceae

BACKGROUND: While most gamma proteobacteria have a single circular chromosome, Vibrionales have two circular chromosomes. Horizontal gene transfer is common among Vibrios, and in light of this genetic mobility, it is an open question to what extent the two chromosomes themselves share a common history since their formation.

RESULTS: Single copy genes from each chromosome (142 genes from chromosome I and 42 genes from chromosome II) were identified from 19 sequenced Vibrionales genomes and their phylogenetic comparison suggests consistent phylogenies for each chromosome. Additionally, study of the gene organization and phylogeny of the respective origins of replication confirmed the shared history.

CONCLUSIONS: Thus, while elements within the chromosomes may have experienced significant genetic mobility, the backbones share a common history. This allows conclusions based on multilocus sequence analysis (MLSA) for one chromosome to be applied equally to both chromosomes.


Alternate JournalBMC Microbiol.
PubMed ID20459749
PubMed Central IDPMC2875227