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Genome biology DOI:10.1186/gb-2011-12-6-r60

Metagenomic biomarker discovery and explanation.

Publication TypeJournal Article
Year of Publication2011
AuthorsSegata, N, Izard, J, Waldron, L, Gevers, D, Miropolsky, L, Garrett, WS, Huttenhower, C
JournalGenome biology
Volume12
Issue6
PagesR60
Date Published2011/06/24
ISSN1465-6906
Abstract

This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.

URLhttp://genomebiology.com/content/12/6/R60
DOI10.1186/gb-2011-12-6-r60
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21702898?dopt=Abstract