Experimental and analytical tools for studying the human microbiome.

Nat Rev Genet
Authors
Keywords
Abstract

The human microbiome substantially affects many aspects of human physiology, including metabolism, drug interactions and numerous diseases. This realization, coupled with ever-improving nucleotide sequencing technology, has precipitated the collection of diverse data sets that profile the microbiome. In the past 2 years, studies have begun to include sufficient numbers of subjects to provide the power to associate these microbiome features with clinical states using advanced algorithms, increasing the use of microbiome studies both individually and collectively. Here we discuss tools and strategies for microbiome studies, from primer selection to bioinformatics analysis.

Year of Publication
2011
Journal
Nat Rev Genet
Volume
13
Issue
1
Pages
47-58
Date Published
2011 Dec 16
ISSN
1471-0064
URL
DOI
10.1038/nrg3129
PubMed ID
22179717
PubMed Central ID
PMC5119550
Links
Grant list
U54HG004969 / HG / NHGRI NIH HHS / United States
P01 DK078669 / DK / NIDDK NIH HHS / United States
R01 MD011389 / MD / NIMHD NIH HHS / United States
T32 GM008759 / GM / NIGMS NIH HHS / United States
R01 HG004872 / HG / NHGRI NIH HHS / United States
Howard Hughes Medical Institute / United States
U54 HG004969 / HG / NHGRI NIH HHS / United States