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Nature reviews. Genetics DOI:10.1038/nrg3129

Experimental and analytical tools for studying the human microbiome.

Publication TypeJournal Article
Year of Publication2011
AuthorsKuczynski, J, Lauber, CL, Walters, WA, Parfrey, LW, Clemente, JC, Gevers, D, Knight, R
JournalNature reviews. Genetics
Volume13
Issue1
Pages47-58
Date Published2011/12/16
ISSN1471-0056
Abstract

The human microbiome substantially affects many aspects of human physiology, including metabolism, drug interactions and numerous diseases. This realization, coupled with ever-improving nucleotide sequencing technology, has precipitated the collection of diverse data sets that profile the microbiome. In the past 2 years, studies have begun to include sufficient numbers of subjects to provide the power to associate these microbiome features with clinical states using advanced algorithms, increasing the use of microbiome studies both individually and collectively. Here we discuss tools and strategies for microbiome studies, from primer selection to bioinformatics analysis.

URLhttp://dx.doi.org/10.1038/nrg3129
DOI10.1038/nrg3129
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/22179717?dopt=Abstract