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PLoS medicine DOI:10.1371/journal.pmed.0030485

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

Publication TypeJournal Article
Year of Publication2006
AuthorsLee, JC, Vivanco, I, Beroukhim, R, Huang, JH, Feng, WL, Debiasi, RM, Yoshimoto, K, King, JC, Nghiemphu, P, Yuza, Y, Xu, Q, Greulich, H, Thomas, RK, Paez, JG, Peck, TC, Linhart, DJ, Glatt, KA, Getz, G, Onofrio, R, Ziaugra, L, Levine, RL, Gabriel, S, Kawaguchi, T, O'Neill, K, Khan, H, Liau, LM, Nelson, SF, Rao, PN, Mischel, P, Pieper, RO, Cloughesy, T, Leahy, DJ, Sellers, WR, Sawyers, CL, Meyerson, M, Mellinghoff, IK
JournalPLoS medicine
Volume3
Issue12
Pagese485
Date Published2006/12/01
ISSN1549-1277
Abstract

Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory constraints on kinase activity, can promote malignant transformation, and appear to be a major determinant of response to kinase inhibitor therapy. Missense mutations in the EGFR kinase domain, for example, have recently been identified in patients who showed clinical responses to EGFR kinase inhibitor therapy.

URLhttp://dx.plos.org/10.1371/journal.pmed.0030485
DOI10.1371/journal.pmed.0030485
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/17177598?dopt=Abstract