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Trends in molecular medicine DOI:10.1016/j.molmed.2011.01.012

Targeting mutant fibroblast growth factor receptors in cancer.

Publication TypeJournal Article
Year of Publication2011
AuthorsGreulich, H, Pollock, PM
JournalTrends in molecular medicine
Volume17
Issue5
Pages283-92
Date Published2011/05/01
ISSN1471-4914
Abstract

Fibroblast growth factor receptors (FGFRs) play diverse roles in the control of cell proliferation, cell differentiation, angiogenesis and development. Activating the mutations of FGFRs in the germline has long been known to cause a variety of skeletal developmental disorders, but it is only recently that a similar spectrum of somatic FGFR mutations has been associated with human cancers. Many of these somatic mutations are gain-of-function and oncogenic and create dependencies in tumor cell lines harboring such mutations. A combination of knockdown studies and pharmaceutical inhibition in preclinical models has further substantiated genomically altered FGFR as a therapeutic target in cancer, and the oncology community is responding with clinical trials evaluating multikinase inhibitors with anti-FGFR activity and a new generation of specific pan-FGFR inhibitors.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1471-4914(11)00013-X
DOI10.1016/j.molmed.2011.01.012
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21367659?dopt=Abstract