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BMC bioinformatics DOI:10.1186/1471-2105-12-358

Clustering with position-specific constraints on variance: applying redescending M-estimators to label-free LC-MS data analysis.

Publication TypeJournal Article
Year of Publication2011
AuthorsFrühwirth, R, Mani, DR, Pyne, S
JournalBMC bioinformatics
Date Published2011/08/31

Clustering is a widely applicable pattern recognition method for discovering groups of similar observations in data. While there are a large variety of clustering algorithms, very few of these can enforce constraints on the variation of attributes for data points included in a given cluster. In particular, a clustering algorithm that can limit variation within a cluster according to that cluster's position (centroid location) can produce effective and optimal results in many important applications ranging from clustering of silicon pixels or calorimeter cells in high-energy physics to label-free liquid chromatography based mass spectrometry (LC-MS) data analysis in proteomics and metabolomics.