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Circ Res DOI:10.1161/CIRCRESAHA.110.225003

Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.

Publication TypeJournal Article
Year of Publication2011
AuthorsGerszten, RE, Asnani, A, Carr, SA
JournalCirc Res
Date Published2011 Aug 05
KeywordsAnimals, Biomarkers, Cardiovascular Diseases, Humans, Mass Spectrometry, Predictive Value of Tests, Prognosis, Proteins, Proteomics, Reproducibility of Results

Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate new biomarkers and pathways without a prior known association with cardiovascular disease; however, important obstacles remain. In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes.


Alternate JournalCirc. Res.
PubMed ID21817166
PubMed Central IDPMC3973157
Grant ListHHSN268201000033C / HL / NHLBI NIH HHS / United States
R01 HL096738 / HL / NHLBI NIH HHS / United States
HHSN268201000033C / / PHS HHS / United States
R01HL096738-02 / HL / NHLBI NIH HHS / United States