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Circulation research DOI:10.1161/CIRCRESAHA.110.225003

Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.

Publication TypeJournal Article
Year of Publication2011
AuthorsGerszten, RE, Asnani, A, Carr, SA
JournalCirculation research
Volume109
Issue4
Pages463-74
Date Published2011/08/05
ISSN0009-7330
Abstract

Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate new biomarkers and pathways without a prior known association with cardiovascular disease; however, important obstacles remain. In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes.

URLhttp://circres.ahajournals.org/cgi/pmidlookup?view=long&pmid=21817166
DOI10.1161/CIRCRESAHA.110.225003
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21817166?dopt=Abstract