Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.
Circ Res
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Abstract | Despite unmet needs for cardiovascular biomarkers, few new protein markers have been approved by the US Food and Drug Administration for the diagnosis or screening of cardiovascular diseases. Mass spectrometry-based proteomics technologies are capable of identifying hundreds to thousands of proteins in cells, tissues, and biofluids. Proteomics may therefore provide the opportunity to elucidate new biomarkers and pathways without a prior known association with cardiovascular disease; however, important obstacles remain. In this review, we focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes. |
Year of Publication | 2011
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Journal | Circ Res
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Volume | 109
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Issue | 4
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Pages | 463-74
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Date Published | 2011 Aug 05
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ISSN | 1524-4571
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URL | |
DOI | 10.1161/CIRCRESAHA.110.225003
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PubMed ID | 21817166
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PubMed Central ID | PMC3973157
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Grant list | HHSN268201000033C / HL / NHLBI NIH HHS / United States
R01 HL096738 / HL / NHLBI NIH HHS / United States
HHSN268201000033C / PHS HHS / United States
R01HL096738-02 / HL / NHLBI NIH HHS / United States
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