< Back to Publications
Endurance, refuge, and reemergence of dengue virus type 2, Puerto Rico, 1986-2007.
|Publication Type||Journal Article|
|Authors||McElroy, KL, Santiago GA, Lennon NJ, Birren BW, Henn MR, and Muñoz-Jordán JL|
|Abstract||To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994-1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution.|
|Year of Publication||2011|
|Journal||Emerging infectious diseases|
|Date Published (YYYY/MM/DD)||2011/01/01|