Endurance, refuge, and reemergence of dengue virus type 2, Puerto Rico, 1986-2007.
Emerg Infect Dis
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Abstract | To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994-1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution. |
Year of Publication | 2011
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Journal | Emerg Infect Dis
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Volume | 17
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Issue | 1
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Pages | 64-71
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Date Published | 2011 Jan
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ISSN | 1080-6059
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URL | |
DOI | 10.3201/eid1701.100961
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PubMed ID | 21192856
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PubMed Central ID | PMC3204641
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Grant list | HHSN266200400001C / AO / NIAID NIH HHS / United States
HHSN266200400001C / PHS HHS / United States
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