|Publication Type||Journal Article|
|Year of Publication||2001|
|Authors||Clemons, PA, Koehler, AN, Wagner, BK, Sprigings, TG, Spring, DR, King, RW, Schreiber, SL, Foley, MA|
|Journal||Chemistry & biology|
Chemical genetics provides a systematic means to study biology using small molecules to effect spatial and temporal control over protein function. As complementary approaches, phenotypic and proteomic screens of structurally diverse and complex small molecules may yield not only interesting individual probes of biological function, but also global information about small molecule collections and the interactions of their members with biological systems.