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Cell DOI:10.1016/j.cell.2010.02.034

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.

Publication TypeJournal Article
Year of Publication2010
AuthorsHotamışlıgil, GS
Date Published2010 Mar 19
KeywordsAnimals, Endoplasmic Reticulum, Humans, Inflammation, Metabolic Diseases, Protein Folding, Stress, Physiological, Unfolded Protein Response

The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's adaptive capacity results in activation of the unfolded protein response (UPR), which intersects with many different inflammatory and stress signaling pathways. These pathways are also critical in chronic metabolic diseases such as obesity, insulin resistance, and type 2 diabetes. The ER and related signaling networks are emerging as a potential site for the intersection of inflammation and metabolic disease.


Alternate JournalCell
PubMed ID20303879
PubMed Central IDPMC2887297
Grant ListP30 DK040561 / DK / NIDDK NIH HHS / United States
R01 DK064360 / DK / NIDDK NIH HHS / United States
R01 DK064360-07 / DK / NIDDK NIH HHS / United States
P30 DK040561-14 / DK / NIDDK NIH HHS / United States
R01 DK052539 / DK / NIDDK NIH HHS / United States
R01 DK052539-12 / DK / NIDDK NIH HHS / United States