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Nature medicine DOI:10.1038/nm0410-396

Endoplasmic reticulum stress and atherosclerosis.

Publication TypeJournal Article
Year of Publication2010
AuthorsHotamisligil, GS
JournalNature medicine
Volume16
Issue4
Pages396-9
Date Published2010/04/01
ISSN1078-8956
Abstract

Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.

URLhttp://dx.doi.org/10.1038/nm0410-396
DOI10.1038/nm0410-396
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/20376052?dopt=Abstract