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Nat Med DOI:10.1038/nm0410-396

Endoplasmic reticulum stress and atherosclerosis.

Publication TypeJournal Article
Year of Publication2010
AuthorsHotamışlıgil, GS
JournalNat Med
Date Published2010 Apr
KeywordsAnimals, Apoptosis, Atherosclerosis, Endoplasmic Reticulum, Humans, Inflammation, Lipid Metabolism, Macrophages, Stress, Physiological, Unfolded Protein Response

Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.


Alternate JournalNat. Med.
PubMed ID20376052
PubMed Central IDPMC2897068
Grant ListR01 DK052539 / DK / NIDDK NIH HHS / United States
R01 DK052539-11 / DK / NIDDK NIH HHS / United States
R01 DK064360 / DK / NIDDK NIH HHS / United States
R01 DK064360-07 / DK / NIDDK NIH HHS / United States