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Nature DOI:10.1038/nature10487

Corridors of migrating neurons in the human brain and their decline during infancy.

Publication TypeJournal Article
Year of Publication2011
AuthorsSanai, N, Nguyen, T, Ihrie, RA, Mirzadeh, Z, Tsai, H-H, Wong, M, Gupta, N, Berger, MS, Huang, E, Garcia-Verdugo, J-M, Rowitch, DH, Alvarez-Buylla, A
JournalNature
Volume478
Issue7369
Pages382-6
Date Published2011 Sep 28
ISSN1476-4687
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Brain, Cell Movement, Cell Proliferation, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Middle Aged, Neurons, Olfactory Pathways
Abstract

The subventricular zone of many adult non-human mammals generates large numbers of new neurons destined for the olfactory bulb. Along the walls of the lateral ventricles, immature neuronal progeny migrate in tangentially oriented chains that coalesce into a rostral migratory stream (RMS) connecting the subventricular zone to the olfactory bulb. The adult human subventricular zone, in contrast, contains a hypocellular gap layer separating the ependymal lining from a periventricular ribbon of astrocytes. Some of these subventricular zone astrocytes can function as neural stem cells in vitro, but their function in vivo remains controversial. An initial report found few subventricular zone proliferating cells and rare migrating immature neurons in the RMS of adult humans. In contrast, a subsequent study indicated robust proliferation and migration in the human subventricular zone and RMS. Here we find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited window of neurogenesis, not all new neurons in the human subventricular zone are destined for the olfactory bulb--we describe a major migratory pathway that targets the prefrontal cortex in humans. Together, these findings reveal robust streams of tangentially migrating immature neurons in human early postnatal subventricular zone and cortex. These pathways represent potential targets of neurological injuries affecting neonates.

URLhttp://dx.doi.org/10.1038/nature10487
DOI10.1038/nature10487
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/21964341?dopt=Abstract

Alternate JournalNature
PubMed ID21964341
PubMed Central IDPMC3197903
Grant ListR37 NS028478-10 / NS / NINDS NIH HHS / United States
F32 NS058180-01A1 / NS / NINDS NIH HHS / United States
R01 HD032116-11 / HD / NICHD NIH HHS / United States
R01 NS028478 / NS / NINDS NIH HHS / United States
R01 NS028478-17 / NS / NINDS NIH HHS / United States
R37 HD032116-14 / HD / NICHD NIH HHS / United States
R01 NS059893 / NS / NINDS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
K26 OD010927 / OD / NIH HHS / United States
F32 NS058180 / NS / NINDS NIH HHS / United States
K26 RR024858-02 / RR / NCRR NIH HHS / United States
K26 RR024858 / RR / NCRR NIH HHS / United States
F32 NS 058180 / NS / NINDS NIH HHS / United States
R37 HD032116 / HD / NICHD NIH HHS / United States
R01 NS059893-03 / NS / NINDS NIH HHS / United States
R37 NS028478 / NS / NINDS NIH HHS / United States
R01 HD032116 / HD / NICHD NIH HHS / United States