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Genetics DOI:10.1534/genetics.104.031492

Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.

Publication TypeJournal Article
Year of Publication2005
AuthorsSinger, JB, Hill, AE, Nadeau, JH, Lander, ES
JournalGenetics
Volume169
Issue2
Pages855-62
Date Published2005/02/01
ISSN0016-6731
Abstract

Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous reports of quantitative trait loci (QTL) on chromosomes 1, 4, and 15 and identified novel loci on chromosomes 6 and 17. The studies were replicated in two separate laboratories. Systematic differences in the overall activity level were found between the two facilities, but the presence of the QTL was confirmed in both laboratories. We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity.

URLhttp://www.genetics.org/cgi/pmidlookup?view=long&pmid=15371360
DOI10.1534/genetics.104.031492
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/15371360?dopt=Abstract