Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.
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Abstract | Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous reports of quantitative trait loci (QTL) on chromosomes 1, 4, and 15 and identified novel loci on chromosomes 6 and 17. The studies were replicated in two separate laboratories. Systematic differences in the overall activity level were found between the two facilities, but the presence of the QTL was confirmed in both laboratories. We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity. |
Year of Publication | 2005
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Journal | Genetics
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Volume | 169
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Issue | 2
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Pages | 855-62
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Date Published | 2005 Feb
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ISSN | 0016-6731
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URL | |
DOI | 10.1534/genetics.104.031492
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PubMed ID | 15371360
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PubMed Central ID | PMC1449086
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Grant list | HD07518 / HD / NICHD NIH HHS / United States
GM07250 / GM / NIGMS NIH HHS / United States
P40 RR012305 / RR / NCRR NIH HHS / United States
RR12305 / RR / NCRR NIH HHS / United States
T32 HD007518 / HD / NICHD NIH HHS / United States
T32 GM007250 / GM / NIGMS NIH HHS / United States
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