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Genetics DOI:10.1534/genetics.104.031492

Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice.

Publication TypeJournal Article
Year of Publication2005
AuthorsSinger, JB, Hill, AE, Nadeau, JH, Lander, ES
Date Published2005 Feb
KeywordsAnimals, Anxiety, Chromosome Mapping, Chromosomes, Exploratory Behavior, Male, Mice, Mice, Inbred A, Mice, Inbred C57BL, Quantitative Trait Loci

Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous reports of quantitative trait loci (QTL) on chromosomes 1, 4, and 15 and identified novel loci on chromosomes 6 and 17. The studies were replicated in two separate laboratories. Systematic differences in the overall activity level were found between the two facilities, but the presence of the QTL was confirmed in both laboratories. We also identified specific effects on open-field defecation and center avoidance and distinguished them from overall open-field activity.


Alternate JournalGenetics
PubMed ID15371360
PubMed Central IDPMC1449086
Grant ListHD07518 / HD / NICHD NIH HHS / United States
GM07250 / GM / NIGMS NIH HHS / United States
P40 RR012305 / RR / NCRR NIH HHS / United States
RR12305 / RR / NCRR NIH HHS / United States
T32 HD007518 / HD / NICHD NIH HHS / United States
T32 GM007250 / GM / NIGMS NIH HHS / United States