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Bioinformatics (Oxford, England) DOI:10.1093/bioinformatics/bti027

Improving genome annotations using phylogenetic profile anomaly detection.

Publication TypeJournal Article
Year of Publication2005
AuthorsMikkelsen, TS, Galagan, JE, Mesirov, JP
JournalBioinformatics (Oxford, England)
Volume21
Issue4
Pages464-70
Date Published2005/02/15
ISSN1367-4803
Abstract

A promising strategy for refining genome annotations is to detect features that conflict with known functional or evolutionary relationships between groups of genes. Previous work in this area has been focused on investigating the absence of 'housekeeping' genes or components of well-studied pathways. We have sought to develop a method for improving new annotations that can automatically synthesize and use the information available in a database of other annotated genomes.

URLhttp://bioinformatics.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=15374867
DOI10.1093/bioinformatics/bti027
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/15374867?dopt=Abstract