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Mol Psychiatry DOI:10.1038/

Support for involvement of neuregulin 1 in schizophrenia pathophysiology.

Publication TypeJournal Article
Year of Publication2005
AuthorsPetryshen, TL, Middleton, FA, Kirby, A, Aldinger, KA, Purcell, S, Tahl, AR, Morley, CP, McGann, L, Gentile, KL, Rockwell, GN, Medeiros, HM, Carvalho, C, Macedo, A, Dourado, A, Valente, J, Ferreira, CP, Patterson, NJ, Azevedo, MH, Daly, MJ, Pato, CN, Pato, MT, Sklar, P
JournalMol Psychiatry
Pages366-74, 328
Date Published2005 Apr
KeywordsChromosome Mapping, Chromosomes, Human, Pair 8, European Continental Ancestry Group, Family, Female, Genetic Linkage, Genetic Predisposition to Disease, Genomics, Haplotypes, Humans, Male, Microsatellite Repeats, Nerve Tissue Proteins, Neuregulin-1, Pedigree, Polymorphism, Single Nucleotide, Portugal, Reference Values, Schizophrenia

Schizophrenia is a common, multigenic psychiatric disorder. Linkage studies, including a recent meta-analysis of genome scans, have repeatedly implicated chromosome 8p12-p23.1 in schizophrenia susceptibility. More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples. We investigated NRG1 for association in schizophrenia patients of Portuguese descent to determine whether this gene is a risk factor in this population. We tested NRG1 markers and haplotypes for association in 111 parent-proband trios, 321 unrelated cases, and 242 control individuals. Associations were found with a haplotype that overlaps the risk haplotype originally reported in the Icelandic population ("Hap(ICE)"), and two haplotypes located in the 3' end of NRG1 (all P


Alternate JournalMol. Psychiatry
PubMed ID15545978
Grant ListMH 058693 / MH / NIMH NIH HHS / United States
MH 52618 / MH / NIMH NIH HHS / United States