You are here

Genetics DOI:10.1534/genetics.104.032177

A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.

Publication TypeJournal Article
Year of Publication2004
AuthorsPoirier, C, Qin, Y, Adams, CP, Anaya, Y, Singer, JB, Hill, AE, Lander, ES, Nadeau, JH, Bishop, CE
JournalGenetics
Volume168
Issue3
Pages1557-62
Date Published2004/11/01
ISSN0016-6731
Abstract

The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo.

URLhttp://www.genetics.org/cgi/pmidlookup?view=long&pmid=15579706
DOI10.1534/genetics.104.032177
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/15579706?dopt=Abstract