|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Poirier, C, Qin, Y, Adams, CP, Anaya, Y, Singer, JB, Hill, AE, Lander, ES, Nadeau, JH, Bishop, CE|
|Date Published||2004 Nov|
|Keywords||Animals, Crosses, Genetic, Female, Genomic Imprinting, Inbreeding, Male, Mice, Mice, Inbred C57BL, Pedigree, Sex Determination Processes|
The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo.
|PubMed Central ID||PMC1448764|