|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Berger, R, Febbo, PG, Majumder, PK, Zhao, JJ, Mukherjee, S, Signoretti, S, Campbell, KT, Sellers, WR, Roberts, TM, Loda, M, Golub, TR, Hahn, WC|
Androgen ablation is the primary treatment modality for patients with metastatic prostate cancer; however, the role of androgen receptor signaling in prostate cancer development remains enigmatic. Using a series of genetically defined immortalized and tumorigenic human prostate epithelial cells, we found that introduction of the androgen receptor induced differentiation of transformed prostate epithelial cells to a luminal phenotype reminiscent of organ-confined prostate cancer when placed in the prostate microenvironment. Moreover, androgen receptor expression converted previously androgen-independent, tumorigenic prostate epithelial cells into cells dependent on testosterone for tumor formation. These observations indicate that androgen receptor expression is oncogenic and addictive for the human prostate epithelium.