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Cancer Res DOI:10.1158/0008-5472.CAN-04-2938

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.

Publication TypeJournal Article
Year of Publication2004
AuthorsBerger, R, Febbo, PG, Majumder, PK, Zhao, JJ, Mukherjee, S, Signoretti, S, K Campbell, T, Sellers, WR, Roberts, TM, Loda, M, Golub, TR, Hahn, WC
JournalCancer Res
Date Published2004 Dec 15
KeywordsAndrogens, Animals, Cell Differentiation, Cell Transformation, Neoplastic, DNA-Binding Proteins, Epithelial Cells, Gene Expression Profiling, Genes, ras, Humans, Male, Mice, Multigene Family, Prostate, Prostatic Neoplasms, Receptors, Androgen, Telomerase

Androgen ablation is the primary treatment modality for patients with metastatic prostate cancer; however, the role of androgen receptor signaling in prostate cancer development remains enigmatic. Using a series of genetically defined immortalized and tumorigenic human prostate epithelial cells, we found that introduction of the androgen receptor induced differentiation of transformed prostate epithelial cells to a luminal phenotype reminiscent of organ-confined prostate cancer when placed in the prostate microenvironment. Moreover, androgen receptor expression converted previously androgen-independent, tumorigenic prostate epithelial cells into cells dependent on testosterone for tumor formation. These observations indicate that androgen receptor expression is oncogenic and addictive for the human prostate epithelium.


Alternate JournalCancer Res.
PubMed ID15604246
Grant ListK01 CA94223 / CA / NCI NIH HHS / United States
K23 CA089031 / CA / NCI NIH HHS / United States
P01 CA50661 / CA / NCI NIH HHS / United States