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Nature reviews. Genetics DOI:10.1038/nrg1521

Genome-wide association studies for common diseases and complex traits.

Publication TypeJournal Article
Year of Publication2005
AuthorsHirschhorn, JN, Daly, MJ
JournalNature reviews. Genetics
Volume6
Issue2
Pages95-108
Date Published2005/02/01
ISSN1471-0056
Abstract

Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care.

URLhttp://dx.doi.org/10.1038/nrg1521
DOI10.1038/nrg1521
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/15716906?dopt=Abstract