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Nat Rev Genet DOI:10.1038/nrg1521

Genome-wide association studies for common diseases and complex traits.

Publication TypeJournal Article
Year of Publication2005
AuthorsHirschhorn, JN, Daly, MJ
JournalNat Rev Genet
Volume6
Issue2
Pages95-108
Date Published2005 Feb
ISSN1471-0056
KeywordsAnimals, Genetic Predisposition to Disease, Genetic Variation, Genome, Humans, Linkage Disequilibrium, Multifactorial Inheritance, Quantitative Trait, Heritable, Sequence Analysis, DNA
Abstract

Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care.

URLhttp://dx.doi.org/10.1038/nrg1521
DOI10.1038/nrg1521
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/15716906?dopt=Abstract

Alternate JournalNat. Rev. Genet.
PubMed ID15716906